![]() Messenger RNA vaccines get the recipient’s body to produce a viral protein that then stimulates the desired immune response. ![]() ![]() Researchers found a way to introduce and protect an mRNA message with the code for a portion of the spike protein on the SARS-CoV-2 virus’s surface. The goal of a vaccine is to get your immune system to react to a harmless version or part of a germ so when you encounter the real thing you’re ready to fight it off. Harnessing mRNA For VaccinationĪll of mRNA’s characteristics made it of great interest to vaccine developers. Once the instructions vanish, protein production stops until the protein factories receive a new message. These features combine to enable the message to be “read,” translated into proteins, and then quickly destroyed – within minutes for certain proteins that need to be tightly controlled, or up to a few hours for others. Structural features of the mRNA – the U in the code, its single-stranded shape, ribose sugar and its specific sequence – ensure that the mRNA has a short half-life. Messenger RNA instructions are timed to self-destruct, like a disappearing text or snapchat message. No cell wants to produce every protein described in your whole genome all at once. The mRNA also gives the cell a way to control the rate of protein production – turning the blueprints “on” or “off” as needed. When these enzymes recognize the structure and the U in the RNA code, they erase the message, protecting the cell from false instructions. It prevents invaders from hijacking the cellular machinery to produce foreign proteins because any RNA outside of the cell is instantaneously targeted for destruction by enzymes called RNases. Programmed To Self-DestructĪs the intermediary messenger, mRNA is an important safety mechanism in the cell. The process that converts DNA to mRNA to protein is the foundation for how the cell functions. It’s mRNA’s job to help fire up the cellular machinery to build the proteins, as encoded by the DNA, that are appropriate for that time and place. RNA is produced as needed in response to the dynamic cellular environment and the immediate needs of the body. Identical copies of DNA reside in every single cell of an organism, from a lung cell to a muscle cell to a neuron. DNA’s sugar contains one less oxygen atom and this difference is reflected in their names: DNA is the nickname for deoxyribonucleic acid, RNA is ribonucleic acid. Both RNA and DNA structures have a backbone made of sugar and phosphate molecules, but RNA’s sugar is ribose and DNA’s is deoxyribose. The RNA code contains a U instead of a T – uracil instead of thymine. RNA is a single strand of code letters (nucleotides), while DNA is double-stranded. The structure of RNA is similar to DNA but has some important differences. The double-stranded DNA sequence is transcribed into an mRNA code so the instructions can be translated into proteins. Once the mRNA arrives, the cell can produce particular proteins from these instructions. These messages – the mRNA – are transported out to the main part of the cell. Sections of the DNA code are transcribed into shortened messages that are instructions for making proteins. That’s where messenger RNA, or mRNA for short, comes in. Cells rely on proteins to carry out the many processes necessary for the body to function. The genes are the details in the DNA blueprint for all the physical characteristics that make you uniquely you.īut the information from your genes has to get from the DNA in the nucleus out to the main part of the cell – the cytoplasm – where proteins are assembled. It’s protected in a part of the cell called the nucleus. (ttsz/iStock via Getty Images Plus)ĭNA is found inside the cells of every living thing. Messenger RNA carries genetic information from DNA in the highly protected nucleus out to the rest of the cell, where structures called ribosomes can build proteins according to the DNA blueprint. It’s the molecule that contains all of your genes spelled out in a four-letter code – A, C, G and T. Here’s a crash course in just what mRNA is and the important job it does. Scientists think RNA originated in the earliest life forms, even before DNA existed. It evolved billions of years ago and is naturally found in every cell in your body. But mRNA itself is not a new invention from the lab. It’s the key ingredient in the Pfizer and Moderna COVID-19 vaccines. ![]() One surprising star of the coronavirus pandemic response has been the molecule called mRNA. ![]()
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